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however, some patients may still not achieve metabolic targets and efficacy remains considerably less than that seen with bariatric surgery
They set the plan
The authors identified future areas of investigation including male models, long-term treatment effects, and combination with other NAD+ precursors such as NMN
Other important safety considerations include injection site reactions, increased heart rate (a class effect, though potentially more pronounced with liraglutide), and risk of pancreatitis (which requires immediate discontinuation if suspected)
Randomized clinical trial (2025): A double-blind RCT found once-weekly semaglutide reduced alcohol craving and heavy drinking versus placebo in adults with AUD, supporting larger confirmatory trials
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