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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 15% by weight of the poloxamer

Patients often report increased energy levels, better mood, and a general sense of well-being

The synergy between exogenous MOTS-c and exercise is not merely additive: because MOTS-c mimics one of the molecular consequences of high-intensity exercise (AMPK activation via AICAR accumulation), concurrent exercise training may amplify the peptide's effects on GLUT4 translocation and mitochondrial biogenesis

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