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Both routes are covered

In this model, genes associated with the one-carbon metabolic pathways, including the folate and methionine cycles, are up-regulated in the fungal cells upon infection, and are supposed to result in enhanced biosynthesis of nucleotides, NADPH, glutathione and methyl groups

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Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation

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Therefore, FOXO4-DRI shows potential as a keloid treatment to prevent the aggressiveness and relapse of keloids by alleviating the inflammatory microenvironment