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In 1902 they discovered in anaesthetised dogs that a chemical messenger secreted by the intestinal lining into the bloodstream helped to stimulate the pancreas to produce digestive juices whenever food or acid was introduced into the duodenum

According to a 2016 study published in Currents in Neuropharmacology, it may also support the gut-brain barrier, which offers neuroprotective effects ( 7 )

TLDR No validated human dose exists