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Subsequently, at the distal part of the colon, tyrosine, phenylalanine, and tryptophan amino acids from endogenous, dietary, or microbial metabolism (Koppe et al., 2018) are utilized by bacteria for growth, metabolizing them to various end products, including indoles and phenols, which serve as precursors for the formation of cardio- and neuro-toxic uremic toxins (Krukowski et al., 2023)

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