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For example, HepG2 cells exposed to 20 mM APAP for 24 h showed only a minor (8%) reduction in GSH content, a minor increase in protein adducts, no mitochondrial dysfunction and only a 2-fold increase in lactate dehydrogenase (LDH) release [142]

J Mol Cell Cardiol 2000

The key components of this mechanism are oxidant stress, with ferrous iron-mediated Fenton reaction and LPO as the terminal events [62]

J Imaging

However, the sensitivity reduces in younger women with denser breast tissue, resulting in false negatives and delayed diagnoses (188)

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