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At much higher concentrations, melatonin may act as an electron donor, promoting a receptor free non-specific antioxidant response ( Melatonin receptors MT1 and MT2 couple to Gi/o and beta-arrestins and depending on the context also couple to Gq ( Pineal melatonin exerts a wide range of physiological actions due to its release into the cerebrospinal fluid (CSF) and bloodstream

Contrairement aux crmes classiques, la texture huileuse facilite la pntration des actifs et maximise leur efficacit, tout en protgeant la barrire cutane