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Trial Metric Retatrutide 12mg (TRIUMPH-4) Semaglutide 2.4mg (STEP 1) Mean Weight Loss 28.7% at 68 weeks 14.9% at 68 weeks Mechanism Triple agonist (GLP-1/GIP/GCGR) Single agonist (GLP-1) FDA Status Phase 3 (investigational) Approved (Wegovy) Dosing Weekly subcutaneous Weekly subcutaneous Common Adverse Events GI (nausea, vomiting, diarrhea), dysesthesia GI (nausea, vomiting, diarrhea) Important caveat: These results come from different trial populations and study designs

Think fat loss, not muscle If it fits into your budget, a bathroom or home scale which estimates your body fat and muscle percentage can be helpful

If youre interested in finding an alternative to Januvia, talk with your doctor

Berry M, Morgan A, Shaw DE, et al

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Clean the injection site with an alcohol wipe and allow it to dry completely