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Despite the fact that the main function of the MTHFR enzyme is to regulate the availability of 5-MTHF for homocysteine remethylation, the pathological consequences of functional variants of MTHFR gene cannot only be attributed to the increase in homocysteine levels

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Most patients experience no adverse effects, and when present, theyre typically mild and transient including temporary digestive changes as the gut adjusts, minor nausea (usually resolving within days), or altered bowel patterns during initial therapy