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A recent study showed that TMAO induces osteogenic responses in human aortic valve interstitial cells via ERmitochondrial stress in vitro and aggravates aortic valve lesions in mice (72)

[63] have assessed the effect of zinc deficiency and zinc supplementation on antioxidant expression in high-fat diet mice, inducing vascular inflammation and oxidative stress, demonstrating that zinc insufficiency exacerbates antioxidant expression, whereas zinc supplementation improves that expression

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The studys authors reviewed data from 16,827 people

Overcoming the compensatory increase in NRF2 induced by NPL4 inhibition enhances disulfiram/copper-induced oxidative stress and ferroptosis in renal cell carcinoma