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Other environmental medicine literature suggests that for a specific, potentially large subset of patients diagnosed with ME/CFS, systemic mycotoxin toxicity is a primary underlying driver of their debilitating symptoms, rather than an idiopathic or purely post-viral phenomenon

However, in hemorrhagic post-stroke epilepsy and PTE, large amounts of Fe 2+ from red blood cells and hemoglobin are released into the brain, and these Fe 2+ ions may be involved in inducing ferroptosis (Mori et al., 2004)

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When donating an electron, glutathione itself becomes reactive and readily reacts with another reactive glutathione to form GSSG