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NHS-Recommended Ways to Manage Weight Before Pregnancy NICE-supported approaches including a balanced diet, at least 150 minutes of moderate exercise weekly, and NHS Tier 2 weight management programmes are the recommended safe alternatives to medication before conception

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GLP-1 medications like Wegovy and Zepbound have reshaped the weight-loss conversation by helping many people better regulate appetite, feel fuller sooner, and improve blood sugar control

This metabolic inflammatory environment not only promotes diabetes progression by inducing insulin resistance and -cell dysfunction but also fosters a protumor microenvironment by activating key signaling pathways such as nuclear factor kappa-B (NF-B) and signal transducer and activator of transcription 3 (STAT3) (72, 7476)