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Faster titration schedules can produce larger first-month losses but may increase side-effect burden, making the slower approach preferable for many patients

Spaulding SW, Chopra IJ, Swherwin RS, et al

& AlHusseini, N

Lockley SW, Dressman MA, Licamele L et al (2015) Tasimelteon for non-24-hour sleep-wake disorder in totally blind people (SET and RESET): Two multicentre, randomised, double-masked, placebo-controlled phase 3 trials

The second-line ADMs included GLP1-R agonists, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, or sodium-glucose cotransporter 2 (SGLT2) inhibitors

You need 2.6 micrograms of B12 daily while pregnant and 2.8 mcg while breastfeeding