For future large-scale studies or the integration of available methylome level data, the discovery of sufficiently sensitive clinical biomarkers is essential
GLP-1 medications are typically prescribed for individuals who have a body mass index (BMI) of 30 or higher, or for those with a BMI of 27 or higher who also have at least one weight-related health condition, such as type 2 diabetes or high blood pressure
This accelerated decay often occurs even in patients with previously stable oral health and good hygiene habits
These alterations in nutrient absorption can lead to osmotic diarrhea, where unabsorbed nutrients draw water into the intestinal lumen, resulting in watery stool
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Because tirzepatide was only approved by the FDA in mid-2022 for type 2 diabetes, the ability to rigorously analyze its use (on- and off-label) for a broad population of patients with overweight or obesity, not just a subset captured in insurance databases, has the power to greatly improve our understanding of how these agents are being used in every day practice and the effect that theyre having. This research was conducted using Truveta, which offers the most complete, timely, and clean regulatory-grade electronic health record (EHR) data from more than 100 million patients across more than 30 US health systems
