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doi: 10.1038/s41422-022-00653-7 272 TangamornsuksanW.LohitnavyO.SruamsiriR.ChaiyakunaprukN.Norman ScholfieldC.ReisfeldB.et al

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Unlike traditional pharmaceutical interventions that may be taken indefinitely, peptides are typically administered in structured cycles to prevent receptor desensitization and allow the bodys natural homeostatic mechanisms to reset

This work suggests that HGF-MET may also protect from parthanatos, a form of caspase-independent regulated cell death occurring especially in neurons and driven by PARP1 hyperactivation (Galluzzi et al., 2018)

Toldi D, Gyugos M, Dark , Szalai G, Gulys Z, Gierczik K, et al

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