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However, XO-derived RS production is increased in tissues affected by certain diseases, including atherosclerosis (Nasi et al., 2021), rheumatoid arthritis (Hanachi et al., 2009), or Dupuytrens contracture (Murrell and Hooper, 1992)

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for example, salinomycin can drive ferroptosis-based cell death in breast CSCs (Zhao et al., 2019), and ironmycin, a derivative of salinomycin, can specifically trigger iron accumulation in lysosomes, activating cell death pathways consistent with ferroptosis (Mai et al., 2017)

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

[18] The GPX4's appear to play a greater role in the fish GPX system than in mammals