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It exhibits this effect in the presence of the cuprizone toxin, which can cause neuron damage, including demyelination leading to the breakdown of myelin sheaths in the central or peripheral nervous system, without the need to reach the brain
GLP-1 receptor agonists simultaneously target multiple elements of this loop
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Clinical consensus statement development manual
Despite extensive investment in MASH drug development, only one medication (resmetirom) has been officially approved for MASH treatment to date
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