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Recent studies showed that corticosteroids/vitamin D analog combination therapy is more effective than the respective monotherapies in inducing immunomodulation and normalizing keratinocytes [110]

John Wiley & Sons Darmaraki S, Somot S, Sevault F, Nabat P, Narvaez WDC, Cavicchia L, Djurdjevic V, Li L, Sannino G, Sein DV (2019) Future evolution of marine heatwaves in the Mediterranean Sea

Vitamin D upregulates RFC at the blood-brain barrierthe pathway that Leucovorin uses to enter the brain

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However, early responders during (those that lost more than 10% of their starting weight by week 16) saw an average weight loss of 22% by the end of the trial