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Together, these data suggest that impaired GLP-1 post-receptor signaling in the pylorus contributes to the increased GE rate, potentially via reduced effect on pyloric sphincter tone in mice lacking Pam

doi: 10.1016/j.imlet.2009.10.012 45 YagoTNankeYIchikawaNKobashigawaTMogiMKamataniNet al

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Serious complications requiring urgent medical attention include ascending cholangitis (bile duct infection, characterised by Charcot's triad: right upper quadrant pain, fever, and jaundice), gallstone pancreatitis, or gallbladder perforation