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this contributes to mitochondrial ROS accumulation and abnormal autophagic activity, which may drive ferroptosis processes (Liu et al., 2025

Viechtbauer, 2010), employing a random-effect model via the metafor R package (Del, 2015)

Most patients find that the gastrointestinal effects are mild to moderate and become more manageable over time

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Nevertheless, the low or very low certainty of evidence underscores the need for larger population studies with standardized exposure definitions, detailed outcome classification, and comprehensive adjustment for confounding

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