doi: 10.1126/science.93.2426.609
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Illustratively, BPC 157 counteracted lidocaine convulsions [60], and thereby, likely also lidocaines effects on the central nervous system (i.e., inhibiting nicotinic acetylcholine receptors, inhibiting presynaptic calcium channels in the dorsal root ganglion, inhibiting opioid receptors, inhibiting of neurite growth, inhibiting muscarinic cholinergic receptors, and preventing substance P from binding to natural killer (NK) cell receptors) [278,281,282,283]
26 The trial began with single and multiple dose ascending stages in healthy volunteers and extended to elderly non-PD participants in June 2024 to control for age-related effects
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