The main reason for this is that modifiers are used to further describe the particular aspects of a service, whereas HCPCS code S9083 is used to bundle all services under one code
57 ShuX.ZhangY.LiM.HuangX.YangY.ZengJ.et al (2019)
This longevity is itself a proof of concept
They haven't been manufactured under the quality controls required for injectable medications
Companies like Noom and Hims have also launched programs to prescribe microdosed GLP-1s, claiming that these smaller doses can reduce metabolic risk, lower inflammatory markers, and even lower the risk of cognitive decline. Evidence of sustained patient use post-shortage: Prescription volume and utilization of compounded semaglutide and tirzepatide have continued to grow despite the end of medication shortages, suggesting that compounders may be leveraging additives or dosage adjustments to justify production
Hence, by addressing these methodological limitations, such as adequacy of follow-up, generalizability, outcome measures, and small sample sizes, future research can provide more robust evidence of the potential benefits and risks of GLP-1 RAs in psychiatric disorders
