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These include regulation of the systemic metabolic control [23], fine-tuning of the endothelial function via nitric oxide (NO) scavenging and NO bioavailability adjustment [24, 25], modulation of innate immunity (acting as immune sentinels) [26], regulation of cytokine and chemokine levels in circulation [27], and production of ROS via hemoglobin- or heme-mediated pathways (as a part of the immune response to pathogens) [28]

Obesity is a major risk factor for heartburn because like pregnancy the extra weight puts pressure on the stomach, especially when someone reclines, pushing up acid and causing discomfort

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