Faster nutrient absorption and more noticeable results
Because the needle stays in the fatty layer, there is less chance of catching a nerve or a blood vessel than with a deeper injection, which is one reason some clinicians prefer it for maintenance dosing
Separately, another study suggested that longer durations of GLP-1RA treatment may help sustain weight loss even after discontinuation, although this hypothesis remains to be validated
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Some patients report better tolerability when they inject in the evening and sleep through the adjustment period
Superior efficacy with a fixed-ratio com-bination of insulin degludec and liraglutide (IDegLira) compared with insulin degludec and liraglutide in insulin-nave Japanese patients with type 2 diabetes in a phase 3, open-label, randomized trial