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Direct evidence of FATP2-KOinduced cellmediated glucagon-like peptide 1 (GLP-1) secretion included increased GLP-1 + cell mass in FATP2-KO db/db mice, small-molecule FATP2 inhibitor enhancement of GLP-1 secretion in TC1-6 cells and human islets, and exendin[9-39]-inhibitable insulin secretion in FATP2 inhibitortreated human islets

[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Case J., Khan S., Khalid R., Khan A

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Common locations for GLP-1 medication-related cramps: Calf muscles : Frequently reported, especially nocturnal cramps Feet and toes : Often presenting as painful curling or spasms Thigh muscles : Less commonly affected but reported by some patients Abdominal muscles : May be confused with digestive side effects Hands : Occasionally reported, especially with electrolyte imbalances Cramp characteristics: Duration : Typically last from a few seconds to several minutes Intensity : Range from mild tightness to painful spasms Timing : More common at night or after physical activity Trigger patterns : May increase after dose increases or with dehydration Online patient discussions reveal significant individual variation in cramping experiences