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On the one hand, ROS, as a second messenger, can activate MAPK or NF-B pathway and mediate granulocyte macrophage colony-stimulating factor (GM-CSF) production (224), which can interact with RNAKL and M-CSF to promote osteoclast differentiation (225)

BCL3 , an IB family member, is known to inhibit TNF- -induced RelA phosphorylation and may suppress p53 Upregulated Modulator of Apoptosis (PUMA) expression via miR-34a upregulation 65,66

Glutathione is naturally found in the body, and the U.S

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Transcriptome analysis reveals an altered expression profile of zinc transporters in colorectal cancer