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Bessessen says

Because synthetic GLP-1 doesn't break down as easily as the real thing, it can "help create the feeling that you just ate dinner, so you don't want more food," according to Weill Cornell Medicine obesity expert Louis Aronne, MD, whose most recent research on the drugs appeared in the Journal of the American Medical Association in November 2024

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doi: 10.1016/j.jemermed.2022.12.016

Patients have experienced weight reductions ranging from 10% to 15%, which is significant and often accompanied by improvements in blood sugar control and cardiovascular risk factors

Farhadi, A., Sigmund, F., Westmeyer, G