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48,49 Investigating GLP-1 agonism could provide critical insights into restoring metabolic homeostasis in aging tissues and may expand the therapeutic scope of GLP-1 RAs beyond their current indications

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Also, a small non-randomized study 15 in two older adults treated with ALC (2 g/day for 12 weeks), reported a decrease in HDRS scores from 15 to 0 and from 20 to 3 by week 12 and compared outcomes with six non-depressed controls

In schizophrenia, immune activation upregulates pro-inflammatory cytokines (e.g., IFN-, IL-1, TNF-), which activate indoleamine 2,3-dioxygenase (IDO) via both IFN- receptor (IFN-R)-dependent and independent pathways (e.g., synergistic action of TLR4, IL-1R, TNF-R) (215)