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Contaminated, or otherwise poor quality, compounded drug products can lead to serious patient illnesses, including death, it said in 2021

Genetic deletion of HDAC4 in skeletal muscles caused earlier onset of ALS in a mouse model, suggesting a potential risk in use of HDACi for treatment of ALS (Pigna et al., 2019)

AKT activates mammalian target of rapamycin (mTOR), promoting protein synthesis and cell growth