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Most side effects are dose dependent and can be transient

Early studies suggest that a small number of people may experience side effects like difficulty sleeping or a faster heart rate , especially at higher doses

The mechanistic interpretation offered most often is straightforward: recruiting the GIP pathway alongside GLP-1 appears to add to the metabolic effect rather than substitute for it

Significant improvement may take a year or longer, if it occurs

95% CI 1.6, 4.9