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While a standard cigarette holds about 10-12mg of nicotine (absorbing roughly 1-2mg via smoke), a typical pinch of loose chewing tobacco or dip holds significantly more total nicotine mass, leading to higher sustained levels in your system during extended use

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The MOE for the endpoint heart rate acceleration is based on data from Lindgren et al

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This is a negotiable position in most supplier relationships and it is worth having that conversation directly rather than assuming the quoted MOQ is fixed