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"It would be nice to optimize the brain's reward pathway to help our patients out though, and not have them suffer through the cravings." Anhedonia might be a dosing problem, not a drug problem Reports of anhedonia and emotional blunting on GLP-1 agonists have generated real concern

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doi: 10.1016/j.jacc.2024.08.004 99 RiveraFBTangVASDe LunaDVLermaEVVijayaraghavanKKazoryAet al

However, not all studies evaluating use of GLP1-RAs on CV outcomes have shown significant reductions in non-fatal CV events