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Secondly, they need to consider the financial capacity of their customers

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Aqueous and methanol extracts of the leaves of Nicotiana plumbaginifolia Viv (wild tobacco) exhibited good antibacterial activity on five human pathogenic bacteria: Bacillus cereus, Bacillus fusiformis, Salmonella typhimurium Staphylococcus aureus, and Pseudomonas aeruginosa (18)

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"Social reformers and regulation: the prohibition of cigarettes in the United States and Canada." Explorations in Economic History 39.4 (2002): 425-445

The original tobacco factories were built between 1874 and the 1950s