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NQO1, TXNRD1, GCLM/C, GSR, SRXN1) than cigarette smoke [40, 46]

The problem is that the brain starts to rely on nicotine to stimulate these pathways and failing to re-dose leaves the brain without, leading to nicotine withdrawal symptoms

Regarding participants comments, the negative ones concerned primarily the pouch strength (too much nicotine, the hit at the back of the throat was too strong, mouth felt numb) and the unfamiliar format (not comfortable in the mouth, hinders eating and drinking, not pleasant to dispose of)

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it got caught in the mechanics underneath

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