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However, mean HbA 1c for this population was around 64.0 mmol/mol (8.0%), suggesting that either participants had not received appropriate treatment intensification/optimisation or that adherence to treatment prior to trial enrolment was poor

10.1016/j.molcel.2018.10.042 40 GascnS.MurenuE.MasserdottiG.OrtegaF.RussoG

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Phase 2 diabetes trial: Dose-dependent HbA1c reductions minimum effective dose for meaningful glucose control was 4 mg/week (Rosenstock et al., 2023)

doi: 10.1016/j.cjtee.2022.06.002 8