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To date, Nicotine & Tobacco Research has not had an explicit policy on how e-cigarettes should be described, said Munaf

Systems Toxicology Assessments conducted by PMI have indicated a significantly lower and more transient response in terms of gene, microRNA and/or protein expression in cell lines as a result of exposure to experimentally generated aerosols or aqueous extracts from the THS2.2/IQOS heated tobacco product compared to comparable treatments produced from the 3R4F Kentucky Reference cigarette

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Since the aerosol produced by e-cigarettes contains fewer harmful substances than the smoke from traditional tobacco cigarettes, e-cigarette use is associated with fewer health risks for smokers (19)

Its unique blend and commitment to tradition make it the preferred choice for discerning smokers worldwide