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(4) For Smad2 and Wwp2 (also known as AIP2), Wwp2 oppositely regulates TGF- signal transduction to its target genes by participating in both the proteolysis of Smad2 27,28 and the transcriptional activity of Goosecoid (Gsc) 17 or Sox9 29 (see Supplementary Methods (section S1) for details)
Consistent payout speeds across devices signal a platform with synchronized back-end operations
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Amber lights up during both sequences
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