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A decline in higher cortical function may indicate diminished perfusion of the brain, which leads to an altered mental status ranging from confusion and agitation to flaccid coma (Ren & Lenneman, 2019)

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Correction: This story was corrected to clarify the months used in the IDOH analysis

However, like other recent psychiatric MR studies where the exposure instruments included a relaxed statistical threshold, our binge drinking and AUD instruments were comprised of independent SNPs associated with the respective drinking behavior (i.e., P -value 0.001, leaving 141 and 126 MV instruments, respectively (Supplementary Data 5 and 6)