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By contrast, other studies have shown that global GIPR-KO mice are protected from both obesity and insulin resistance when fed a high-fat diet (3135), and GIPR antagonism coupled with GLP-1R agonism leads to weight loss in early clinical trials and mouse models (36, 37), possibly by preventing leptin resistance (16, 38, 39)

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Presence of severe infection, malignancy, recent major surgery, or trauma

It destroys cells that produce pigment, in addition to blocking melanin synthesis

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The mechanism is determined by the active ingredient, not the route of administration