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The identification of a distinct astrocyte subtype that diminishes in Alzheimer's disease

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Complete approach: Semaglutide: Start 0.25mg weekly, increase to 1-2mg weekly over 12 weeks CJC-1295: 1,000mcg twice weekly to preserve muscle during caloric deficit Ipamorelin: 200mcg twice daily for metabolic support Optional: AOD-9604 300mcg daily for targeted fat loss Implementation schedule: Morning: Semaglutide injection (once weekly, same day each week) Morning: Ipamorelin 200mcg + AOD-9604 300mcg before breakfast Evening: Ipamorelin 200mcg before dinner Tuesday/Friday: CJC-1295 1,000mcg Duration: 6-9 months for sustainable fat loss, with potential maintenance phase afterward