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Runx2/Osterix pathway: Upregulation of Runx2 (osteogenic differentiation core transcription factor) and Osterix expression induces directed differentiation of bone marrow mesenchymal stem cells into osteoblasts and increases new bone formation

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GLP-1 seems to keep that process under control

When you diet, your brain senses reduced energy intake and responds by: Increasing hunger hormones Slowing metabolism to conserve energy Intensifying cravings for high-calorie foods Making you feel tired, irritable, or obsessed with food These responses are designed to protect you from starvation

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He advises train hard, recover harder, using HRV and inflammation markers to guide load management