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This stigma can lead people to avoid screening and early diagnosis, said William Cance, M.D., chief medical and scientific officer, American Cancer Society, in a news release

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It is then metabolized to adenosine monophosphate (AMP) via ectonucleoside triphosphate diphosphohydrolase-1 (CD39) and further hydrolyzed to adenosine via ecto-5-nucleotidase (CD73)

The most common example is when there are two genes that contribute a relatively similar amount to the overall metabolism of the medication, but one has increased activity and the other has decreased activity

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