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PIONEER 3 PIONEER 3 compared the efficacy and safety of the addition of oral semaglutide or the DPP-4 inhibitor sitagliptin as add-on therapy in patients with T2DM receiving metformin with or without a sulfonylurea

Side Effects at Different Dose Levels Side effect frequency and intensity change as you progress through the dosing schedule

This view suggests that semaglutide captures most of the available benefit from incretin-based therapy, and tirzepatides advantage comes from fine-tuning rather than fundamentally different mechanisms

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