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[4] Diagnosis is then typically confirmed by ultrasound

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GHRH acts on the somatotrophs via a seven trans-membrane G protein-coupled stimulatory cell-surface receptor

504,505,506 GLP-1 enhances the insulin signaling pathway in the liver by activating the GLP-1R, especially through the phosphorylation of insulin receptor substrates and the activation of the PI3K/Akt signaling pathway, thereby increasing hepatic insulin sensitivity, facilitating glucose uptake and utilization, and reducing hepatic gluconeogenesis